Behavioural toxicology testing involves the use of standardised tests to assess the effects of chemical, physical or biological agents on behaviour.

Toxic agents can impact behaviour in various ways, including altering the brain's neurotransmitter systems or damaging brain cells. Behavioural toxicology testing assesses the potential adverse effects of perception, cognition and mood.

For psychedelic drug developers, behavioural testing can help assess changes in cognitive function, motor activity, and sensory perception as well as identify potential risks associated with long term exposure to these substances.

Regulatory agencies require behavioural toxicology testing as part of the drug approval process for psychedelics to demonstrate their safety and efficacy, and ensure they are suitable for clinical use.

By understanding the effects of toxic agents on behaviour, researchers can develop more effective treatments for neurological and psychiatric disorders, as well as improve understanding of basic brain function.

How is it done?

In general, behavioural toxicity testing involves administering a test substance to a group of animals and comparing their behaviour to that of a control group.

We use video tracking analysis to understand the effects of substances on different behaviours, including memory function and anxiety levels, and the results are analysed statistically to determine the significance of the observed effects.

The Open Field maze can be used to measure anxiolytic effects and effects on ambulation.

The Elevated Plus maze can be use to measure anxiety-like behaviour.

The Y maze and T maze can be used to measure effects on exploratory behaviour, cognitive function, and risk-taking behaviour.

The von Frey test assesses nociceptive sensitisation and profiles a substance's effectiveness for pain control.