Major pharmaceutical companies and scientific researchers continue to invest a lot of energy and financial resources hoping to develop new drugs with stronger analgesic effect, longer duration and lower side effects, for the benefit of mankind.

Physical pain can be acute and chronic, inflammatory and neurological, central and peripheral. Therefore, various analgesics with different mechanisms of action and different types of analgesia need to be evaluated by corresponding animal models before clinical trials. When animals experience pain during an experimental protocol, a cascade of physiological, hormonal, biochemical, and behavioral alterations are triggered that’s similar to human reactions.

Animal models of pain are designed to mimic distinct clinical diseases to better evaluate underlying mechanisms and potential treatments. Outcome measures are designed to measure multiple parts of the pain experience including reflexive hyperalgesia measures, sensory and affective dimensions of pain and impact of pain on function and quality of life.

Currently, Medicilon possess different types of pain models including acute pain, inflammatory pain, and neuropathic pain. We have developed many common methods used for inducing each of the pain phenotypes related to clinical pain syndromes, as well as the main behavioral tests for assessing pain in each model. We have developed a variety of clinically relevant pain models that have been validated to effectively test new therapeutic candidates.

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