Preclinical CVD Efficacy Evaluation
Exploring clinical treatments for stroke
Stroke is the scientific name of cerebralvascular accident, which generally refers to ischemic or hemorrhagic diseases of the heart, brain and tissues of the whole province caused by hyperlipidemia, blood clotting, atherosclerosis, hypertension, etc. It is a sudden onset of cerebral blood circulation disorders.
The clinical manifestations are mainly characterized by sudden dizziness, unconsciousness, or sudden deviated eyes, hemiplegia, and intellectual disability. Stroke mainly includes ischemic stroke (transient ischemic attack, atherosclerotic thrombotic cerebral infarction, lacunar cerebral infarction, cerebral embolism) and hemorrhagic stroke (cerebral hemorrhage, subarachnoid hemorrhage).
For the preclinical development of stroke drugs, the two mountains of pharmacokinetics and pharmacodynamics cannot be avoided, and the models used in both pharmacokinetics and pharmacodynamics are particularly important.